I was wondering if anybody knows of any free tools to generate a series of synthetically accessible compounds from one lead compound? I came across this paper (http://www.ploscompbiol.org/article/info%3Adoi%2F10.1371%2Fjournal.pcbi.1002380) which looks really interesting, but I don’t think the software is freely available.
The idea is that a single compound is used as input and by combining it with a series of available chemical starting blocks and a series of standard reactions it can be transformed into new compounds that chemists might like to make.
Does anybody have any experience such tools?
Thanks for any pointers