as I said some time ago, I’m a bioinformatician, but I like hanging around this forum, I find it really interesting. I feel our interests will do nothing but converge in the near future.
Here is my question:
I have a set of 800 FDA-approved drugs. If I go to DrugBank, I find that, on average, these drugs target 3 proteins. However, if I use STITCH 3 with human proteins and a confidence score above 900 (regarded as highest confidence), I find that these drugs interact, on average, with 27 proteins (!).
I’ve found some papers stating that, on average, the polypharmacology of drugs is around 6 targets. Then, why STITCH 3 is reporting so many interactions? A ‘target’ is different than a ‘protein’?
Sorry guys if this question is naive.