I agree with Rich, it makes much more sense to me to focus on chemistry-and-computers topics than BO and ODOSOS. As a proof of concept, I posted a question about something I've been having problems with lately (batch image generation of molecules), and within hours I had two answers and was generating hundreds of images automatically. Now, that's what I call useful!
In my opinion, this exchange should be mainly about solving technical problems related to computers and chemistry, backed/promoted/organized by the BlueObelisk. If the questions involve something that is not "open", perhaps you could implement some kudos system that rewards Open Source answers?
Personally, I would also be interested in questions/answers about computational chemistry and perhaps quantum chemistry.
As a side note, I found chemistry.stackexchange.com, but it looks like it hasn't taken off at all.